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Creatine phosphokinase (CPK) is an enzyme in the body toàn thân. It is found mainly in the heart, brain, & skeletal muscle. This article discusses the thử nghiệm lớn measure the amount of CPK in the blood.

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A blood sample is needed. This may be taken from a vein. The procedure is called a venipuncture.

This demo may be repeated over 2 or 3 days if you are a patient in the hospital.


No special preparation is needed most of the time.

Tell your health care provider about any medicines you are taking. Drugs that can increase CPK measurements include amphotericin B, certain anesthetics, statins, fibrates, dexamethasone, alcohol, và cocaine.


You may feel slight pain when the needle is inserted to lớn draw blood. Some people feel only a prichồng or stinging sensation. Afterward, there may be some throbbing.


When the total CPK level is very high, it most often means there has been injury or ức chế to lớn muscle tissue, the heart, or the brain.

Muscle tissue injury is most likely. When a muscle is damaged, CPK leaks inkhổng lồ the bloodstream. Finding which specific form of CPK is high helps determine which tissue has been damaged.

This demo may be used to:

Determine if or how badly a muscle is damaged

The pattern và timing of a rise or fall in CPK levels can be significant in making a diagnosis. This is particularly true if a heart attaông xã is suspected.

In most cases other tests are used instead of or with this demo khổng lồ diagnose a heart attaông chồng.


Total CPK normal values:

10 khổng lồ 1trăng tròn micrograms per liter (mcg/L)

Normal value ranges may vary slightly aao ước different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific thử nghiệm results.


High CPK levels may be seen in people who have:

Brain injury or strokeDelirium tremensDermatomyositis or polymyositisHeart attackInflammation of the heart muscle (myocarditis)Lung tissue death (pulmonary infarction)Muscular dystrophiesMyopathy

Other conditions that may give sầu positive demo results include:

Hyperthyroidism

Risks associated with having blood drawn are slight but may include:

Excessive bleedingFainting or feeling lightheadedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)

Other tests should be done to find the exact location of muscle damage.

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Factors that may affect thử nghiệm results include cardiac catheterization, intramuscular injections, trauma to muscles, recent surgery, and heavy exercise.


Anderson JL. St segment elevation axinh đẹp myocardial infarction & complications of myocardial infarction. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 73.

Carty RPhường, Pincus MR, Sarafraz-Yazdi E. Clinical enzymology. In: McPherson RA, Pincus MR, eds. Henry"s Clinical Diagnosis và Management by Laboratory Methods. 23rd ed. Philadelphia, PA: Elsevier; 2017:chap đôi mươi.

Mccullough PA. Interface between renal disease and cardiovascular illness. In: Zipes DPhường, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald"s Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 98.

Nagaraju K, Gladue HS, Lundberg IE. Inflammatory diseases of muscle and other myopathies. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O"Dell JR, eds. Kelley and Firestein"s Textbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier Saunders; 2017:chap 85.


Updated by: Michael A. Chen, MD, PhD, Associate Professor of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington Medical School, Seattle, WA. Also reviewed by David Zieve sầu, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, và the A.D.A.M. Editorial team.


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